Blockade of glucocorticoid excess at the tissue level: inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 as a therapy for type 2 diabetes

J Med Chem. 2008 Aug 28;51(16):4851-7. doi: 10.1021/jm800369f. Epub 2008 Jul 22.

Authors

Christopher Fotsch¹, Minghan Wang

Affiliation

¹ Department of Medicinal Chemistry, Amgen Inc, Thousand Oaks, California 91320, USA.

PMID: 18652443
DOI: 10.1021/jm800369f

No abstract available

MeSH terms

11-beta-Hydroxysteroid Dehydrogenases / antagonists & inhibitors*
11-beta-Hydroxysteroid Dehydrogenases / physiology
Animals
Carbenoxolone / therapeutic use
Diabetes Mellitus, Type 2 / drug therapy*
Enzyme Inhibitors / therapeutic use*
Glucocorticoids / antagonists & inhibitors*
Glucocorticoids / metabolism
Glycyrrhetinic Acid / therapeutic use
Humans
Insulin Resistance / physiology
Obesity / enzymology

Substances

Enzyme Inhibitors
Glucocorticoids
11-beta-Hydroxysteroid Dehydrogenases
Carbenoxolone
Glycyrrhetinic Acid